Real-Time PCR Assay for Genotyping of 19 High-risk HPVs and 2 low-risk HPVs
Human papillomavirus (HPV) is a sexually transmitted DNA virus that establishes infection in squamous epithelialcells in the human body. There are more than 200 types of HPV, which can be classified into high or low-risktypes depending upon their oncogenic potentials.High-risk HPVs also called oncogenic HPVs, which have been confirmed to cause cancer, such as HPV16 and 18.And some HPVs are possibly carcinogenic to humans, like HPV26, 53, 66, 70, 73 and 82, that be classified as high-risk or probably high-risk HPVs. Low-risk HPVs can cause genital warts and low-grade changes in thecells, but rarely cause cancer, such as HPV6 and 11.
High-risk HPV infection is a necessary for the development of cancers of theuterine cervix, which has been firmly established. Approximately 99.7% of cervical cancers are caused by high-risk HPV infection. In particular, HPV16 and HPV18 are known to cause around 70% of cervical cancer cases.