Description
Betacellulin is an EGF-related polypeptide growth factor that signals through the EGF receptor. It is produced in several tissues, including the pancreas, small intestine, and in certain tumor cells. Betacellulin is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. Human Betacellulin is initially synthesized as a glycosylated 32.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce the mature sequence.
Full Name
Betacellulin
Source
E. coli
Species
Human
Accession #
P35070
Molecule Weight
The mature recombinant human BTC is a 9 kDa protein containing 80aa (D32-Y111).
Purity
> 95 % as determined by SDS-PAGE
Endotoxin
< 0.1 EU per μg of the protein as determined by the LAL method
Activity
The ED50 was determined by the dose-dependent stimulation of the proliferation of murine Balb/3T3 cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107units/mg.
Storage
-80 °C, avoid repeated freeze-thaw cycles.
Storage Buffer
PBS