Description
FGF-9, also called HBGF-9 (heparin-binding growth factor-9) and GAF (glia-activating factor), is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion.
FGF-9 exhibits a growth-stimulating effect on cultured glial cells. In nervous system, this protein is produced mainly by neurons and may be important for glial cell development. FGF-9 may have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors.
Full Name
Fibroblast Growth Factor 9
Source
E. coli
Species
Human
Accession #
P31371
Molecule Weight
The mature recombinant human FGF-9 consists of 207 amino acids (2-208) and has a predicted molecular mass of 23.4 kDa.
Purity
> 95 % as determined by SDS-PAGE
Endotoxin
< 0.1 EU per μg of the protein as determined by the LAL method
Activity
Measured in a cell proliferation assay using Balb/3T3 mouse embryonic fibroblast cells. The ED50 for this effect is 1-5 ng/mL.
Storage
-80 °C, avoid repeated freeze-thaw cycles.
Storage Buffer
PBS