Recombinant Human IL-33

Description
Human IL-33 is a proinflammatory protein that shares structural and functional characteristics with the IL-1 cytokine family. It binds and signals through the IL-1RL1/ST2 receptor, to activate NF-κB and MAP kinases. IL-33 induces production of TH2 cell related cytokines, including IL-4, IL-5 and IL-13, and exerts multiple inflammation related bioactivities.

Full Name
Human Interleukin 33

Source
E. coli

Species
Human

Molecule Weight
Recombinant Human IL-33 is a 17.9 kDa protein containing 159 amino acid residues (Ser112-Thr270).

Accession #
O95760

Purity
> 95 % as determined by SDS-PAGE

Endotoxin
< 0.1 EU per μg of the protein as determined by the LAL method

Activity
Measured in a cell proliferation assay using D10.G4.1 mouse helper T cells. The ED50 for this effect is 0.06-0.24 ng/mL. 

Storage
-80 °C, avoid repeated freeze-thaw cycles.

Storage Buffer
PBS