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Recombinant Human BMP-4 Protein

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BMP4-100

BMP-4 is a member of the Bone Morphogenetic Protein (BMPs) family, which is important for the development of bone and cartilage.

Description
BMP-4 is a member of the Bone Morphogenetic Protein (BMPs) family, which is important for the development of bone and cartilage. BMPs belong to the TGF-β superfamily of structurally related signaling proteins. BMP proteins are synthesized as large precursor molecules that are cleaved by proteolytic enzymes. The active form of BMPs can consist of a dimer of two identical proteins or a heterodimer of two related bone morphogenetic proteins. BMPs signal through type I and type II receptor tyrosine kinases and signal through SMAD proteins.
BMP-4 has an important role in postnatal tooth cytodifferentiation. Overexpression BMP-4 has been associated with fibrodysplasia ossificans progressiva (FOP). 

Full Name
Bone morphogenetic protein 4

Source
E. coli

Species
Human

Accession #
Q53XC5

Molecule Weight
The mature recombinant human BMP-3 consists of 116 amino acids (293-408) and has a predicted molecular mass of 13 kDa.

Purity
> 95 % as determined by SDS-PAGE

Endotoxin
< 0.1 EU per μg of the protein as determined by the LAL method

Activity
Measured by its ability to induce alkaline phosphatase production by ATDC5 mouse chondrogenic cells. The ED50 for this effect is typically 2.5-15 ng/mL.

Storage
-80 °C, avoid repeated freeze-thaw cycles.

Storage Buffer
PBS

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