Description
BMP-5 is a member of the Bone Morphogenetic Protein (BMPs) family, which is important for the development of bone and cartilage. BMPs belong to the TGF-β superfamily of structurally related signaling proteins. BMP proteins are synthesized as large precursor molecules that are cleaved by proteolytic enzymes. The active form of BMPs can consist of a dimer of two identical proteins or a heterodimer of two related bone morphogenetic proteins. BMPs signal through type I and type II receptor tyrosine kinases and signal through SMAD proteins.
BMP-5 is expressed in the nervous system, lungs and liver. It is a known regulator for dendritic growth in sympathetic neurons.
Full Name
Bone morphogenetic protein 5
Source
E. coli
Species
Human
Accession #
P22003
Molecule Weight
The mature recombinant human BMP-5 consists of 148 amino acids (317-454) and has a predicted molecular mass of 19 kDa.
Purity
> 95 % as determined by SDS-PAGE
Endotoxin
< 0.1 EU per μg of the protein as determined by the LAL method
Activity
Measured by its ability to induce alkaline phosphatase production by ATDC5 mouse chondrogenic cells. The ED50 for this effect is 0.5-2 µg/mL.
Storage
-80 °C, avoid repeated freeze-thaw cycles.
Storage Buffer
PBS