Recombinant Human Wnt-1 Protein

Description
The Wnts is a large family of secreted proteins with roles in pattern formation, cell fate decision, axon guidance, and tumor formation. Wnt signaling induces and maintains the transformed phenotype and, in certain embryonic cell lines, supports self-renewal in the absence of significant differentiation. Elevated levels of Wnt proteins are associated with tumorigenesis and are present in numerous human breast cancers. Wnt family members are highly hydrophobic, and possess 22 to 24 conserved cysteines.
Wnt-1 is a secreted protein that signals through the Frizzled family of cell surface receptors. Wnt-1 is required for normal embryonic development. Wnt-1 activation induces a complex signaling cascade that ultimately leads to the increased expression of over 50 genes. An important component of Wnt-1 signaling is the stabilization, and resulting accumulation, of the intracellular signaling protein, β-catenine.

Full Name
Wingless-type MMTV Integration Site Family Member 1

 Source
E. coli

Species
Human

Accession #
P0468

 Molecule Weight
The mature recombinant human Wnt-1 is a 38.4 kDa protein containing 343aa.

Purity
> 95 % as determined by SDS-PAGE

Endotoxin
< 0.1 EU per μg of the protein as determined by the LAL method

Storage
-80 °C, avoid repeated freeze-thaw cycles.

Storage Buffer
PBS