NRAS Mutation Detection Kit (bulk)

Detection of 16 mutations in NRAS codons 12, 13, 59, 61, 117 and 14

NRAS is a member of the RAS family of small GTPases and plays a central role in the MAPK signaling pathways.NRAS has been implicated in the pathogenesis of several cancers. NRAS mutations are particularly common in melanoma, hepatocellular carcinoma, myeloid leukemias, and thyroid carcinoma. In total, activating mutations in the NRASgenes occur in 13~25% of cutaneous melanomas, 1~6% of colorectal cancer and 1% of lung cancer, mainly in exons 2, 3 or 4.

The mutation status of NRAS gene is relevant to drug resistance of non-small cell lung cancer treated with tyrosine kinase inhibitors. As a result, NRAS mutations detection supplies evidence for targeted clinical therapy of tumor patients.