FOR IMMEDIATE RELEASE

New ChimerMarker® software version enhances workflow at Penn Medicine
January 19, 2017, State College PA SoftGenetics announced the availability of the latest version of
ChimerMarker software. ChimerMarker software, automated chimerism analysis software, integrates speed and
accuracy with a biologist‐friendly interface. The software can be used to monitor chimerism levels in both
allogeneic and autologous stem cells transplant or hematopoietic stem cells transplant, bone marrow transplant
post bone marrow engraftment, cord and peripheral blood stem cells transplant (PBSCT) samples.
The latest version, incorporates new functionalities, developed in collaboration with Dr. Vivianna Van Deerlin,
Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania, to meet the
needs of leading edge HLA, Molecular Pathology, Histocompatibility, transplant, and immunology laboratories.
Dr. Van Deerlin indicates: “My laboratory which has a high volume of allogeneic stem cell transplants, instituted
ChimerMarker for analysis of chimerism several years ago, using a laboratory‐developed workflow. While we
were happy with the custom workflow and results, there were some features of the software which we felt could
be improved. We approached SoftGenetics with our suggestions and they responded very quickly by making
significant improvements to the features. For example, as part of our workflow we ignore certain markers for each
recipient/donor pair based on its ability to provide an accurate, sensitive, and specific result. In the original
version of the software for each post‐transplant sample we had to ignore each marker one by one in each posttransplant
sample—very time consuming. In the updated version, not only can we ignore multiple markers with
one click, we can also choose to ignore each marker in all current and future samples in the project. Although
longitudinal curves were available in the original version, all the sample types were mixed together and the
process of looking at one or another sample type like blood and T cells was cumbersome. In addition, there was no
option to just view stutter adjusted values. In the updated version plots each sample type charts as a different line
with the option to view only stutter adjusted data and it is very easy to view and modify the longitudinal plots.
There were many other large and small improvements including the ability to calculate age from date of birth and
to sort the samples by run date that made our workflow more efficient. SoftGenetics really listened to our needs
and responded by improving the ChimerMarker software. Everyone in the lab who uses the software is thrilled
with the changes.”
In addition to the workflow additions, ChimerMarker is now compatible with Six Dye Chemistries – enabling
labs to analyze results from more loci from human ID kits such as Fusion®6C, Globalfiler® and
Investigator®24Plex; new User interface additions providing more options and streamline Chimerism Analysis
settings and reporting.
Further details and software trials are available to interested parties: http://www.softgenetics.com/chimerMarker.php