7M Guanidine HCl Solution

Description
MCLAB’s 7M Guanidine-HCl Solution is a ready-to-use solution of guanidine hydrochloride, which can be easily diluted and pH-adjusted to any concentration below 7M. In addition to increasing solubility of hydrophobic molecules, guanidine is a general protein denaturant, unfolding proteins and altering their structures. This can cause some proteins to be irreversibly altered upon interaction with guanidine solutions and may lose their binding function. Before any significant use of guanidine, it is best to experiment with a small amount of the sample and conclude whether the denaturing effects will adversely affect the intended use of the protein.

Applications

Solubilizing proteins from inclusion bodies

Increasing solubility of hydrophobic peptides and proteins

Denaturing proteins

Recommended Storage Condition
Store at room temperature

Caution: EXTREMELY CORROSIVE, HANDLE WITH CARE! Avoid ingestion and contact with skin.