Human Brain-Derived Neurotrophic Factor (BDNF) is a member of the Nerve growth factor family. BDNF is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. During development, BDNF promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems.
Description
Human Brain-Derived Neurotrophic Factor (BDNF) is a member of the Nerve growth factor family. BDNF is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. During development, BDNF promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. It participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. It functions as the major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.
Full Name
Human Brain-Derived Neurotrophic Factor
Source
E. coli
Species
Human
Accession #
P23560
Molecule Weight
The mature recombinant human BDNF consists of 119 amino acids (129-247) and has a predicted molecular mass of 27 kDa. BDNF exists as a homodimer in solution.
Purity
> 95 % as determined by SDS-PAGE
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
Activity
ED50 = 1 - 3 µg/mL as measured by the ability of the protein to induce the proliferation of C6 glioma cells.
Storage
-80 °C, avoid repeated freeze-thaw cycles.
Storage Buffer
PBS
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Human Brain-Derived Neurotrophic Factor (BDNF) is a member of the Nerve growth factor family. BDNF is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. During development, BDNF promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems.
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