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Description
Ciliary neurotrophic factor (CNTF) s a polypeptide initially purified from chick embryo ocular tissue and identified as a trophic factor for embryonic chick ciliary parasympathetic neurons in culture. Subsequent studies have demonstrated that CNTF is a survival factor for additional neuronal cell types including dorsal root ganglion sensory neurons, sympathetic ganglion neurons, embryonic motor neurons, major pelvic ganglion neurons and hippocampal neurons. CNTF has also been shown to prevent the degeneration of motor axons after axotomy.
Full Name
Human Ciliary neurotrophic factor
Source
E. coli
Species
Human
Accession #
P26441.1
Molecule Weight
The mature recombinant human CNTF consists of 199 amino acids (2-200) and has a predicted molecular mass of 22.8 kDa as a dimer.
Purity
> 95 % as determined by SDS-PAGE
Endotoxin
< 0.1 EU per μg of the protein as determined by the LAL method
Activity
Fully biologically active when compared to standard. The ED50 as determined by the dose-dependant stimulation of TF-1 cells is less than 3.0 ng/ml.
Storage
-80 °C, avoid repeated freeze-thaw cycles.
Storage Buffer
PBS
CNTF-100
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