Recombinant Human FGF-4 Protein

Description
Fibroblast growth factor 4 is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. 
FGF-4 is also known as FGF-K and K-FGF, plays a role in a number of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF4 possess oncogenic transforming activity, and functions in bone morphogenesis and limb development through the sonic hedgehog(SHH) signaling pathway.

Full Name
Human Fibroblast Growth Factor 4

Source
E. coli

Species
Human

Accession #
P08620

Molecule Weight
The mature recombinant human FGF-4 consists of 153 amino acids (54-206) and has a predicted molecular mass of 19.7 kDa.

Purity
> 95 % as determined by SDS-PAGE

Endotoxin
< 0.1 EU per μg of the protein as determined by the LAL method

Activity
Measured in a cell proliferation assay using NR6R­3T3 mouse fibroblast cells. The ED50 for this effect is 0.25-1.25 ng/mL.

Storage
-80°C, avoid repeated freeze-thaw cycles.

Storage Buffer
PBS