Recombinant Human KGF/FGF-7 Protein

Description
KGF (keratinocyte growth factor), also known as FGF-7, is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. 
KGF/FGF-7 is a mitogen factor specific for epithelial cells and keratinocytes. KGF/FGF-7 signals through FGFR 2b. KGF/FGF-7 plays a role in kidney and lung development, as well as in angiogenesis and wound healing. 

Full Name
Human Keratinocyte Growth Factor/Fibroblast Growth Factor 7

Source
E. coli

Species
Human

Accession #
P21781

Molecule Weight
The mature recombinant human KGF/FGF-7 consists of 163 amino acids (32-194) and has a predicted molecular mass of 19 kDa.

Purity
> 95 % as determined by SDS-PAGE

Endotoxin
< 0.1 EU per μg of the protein as determined by the LAL method

Activity
Measured in a cell proliferation assay using 4MBr­5 rhesus monkey epithelial cells. The ED50 for this effect is typically 6-60 ng/mL.

 Storage
-80 °C, avoid repeated freeze-thaw cycles.

Storage Buffer
PBS