Recombinant Human FGF-17 Protein

Description
FGF-17 is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. 
FGF17 signals through the FGFR 1c, 2c, 3c, and 4. FGF-17 promotes the induction and patterning of brain development during embryogenesis.

Full Name
Fibroblast Growth Factor 17

Source
E. coli

Species
Human

Accession #
O60258

Molecule Weight
The mature recombinant human FGF-17 consists of 184 amino acids (23-216) and has a predicted molecular mass of 22.6 kDa.

Purity
> 95 % as determined by SDS-PAGE

Endotoxin
< 0.1 EU per μg of the protein as determined by the LAL method

Activity
Measured in a cell proliferation assay using NR6R‑3T3 mouse fibroblast cells. The ED50 for this effect is 100‑500 ng/mL, in the presence of 1 µg/mL heparin.

Storage
-80 °C, avoid repeated freeze-thaw cycles.

Storage Buffer
PBS