Recombinant Human FGF-20 Protein

Description
FGF-20 is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. 
FGF-20 shares a high degree of homology with FGF-9 and FGF-16. The group of receptors which FGF-20 binds to comprises of FGFR1c, FGFR2c, FGFR3b, FGFR3c and FGFR4. It is shown that FGF-20 is found in a variety of cells, including but limited to, dopaminergic neurons, fibroblasts, keratinocytes and breast epithelium.

Full Name
Fibroblast Growth Factor 20

Source
E. coli

Species
Human

Accession #
Q9NP95

Molecule Weight
The mature recombinant human FGF-20 consists of 211 amino acids (1-211) and has a predicted molecular mass of 24 kDa.

Purity
> 95 % as determined by SDS-PAGE

Endotoxin
< 0.1 EU per μg of the protein as determined by the LAL method

Activity
Measured in a cell proliferation assay using NR6R‑3T3 mouse fibroblast cells. The ED50 for this effect is 0.2-1 ng/mL in the presence of 1 µg/mL of heparin.

Storage
-80 °C, avoid repeated freeze-thaw cycles.

Storage Buffer
PBS