Recombinant Human FGF-21 Protein

Description
FGF-21 is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. 
FGF-21, in the presence of β-Klotho as a protein cofactor, signals through the FGFR 1c and 4 receptors, and stimulates insulin-independent glucose uptake by adipocytes.

Full Name
Fibroblast Growth Factor 21

Source
E. coli

Species
Human

Accession #
Q9NSA1

Molecule Weight
The mature recombinant human FGF-21 consists of 181 amino acids (29-209) and has a predicted molecular mass of 20 kDa.

Purity
> 95 % as determined by SDS-PAGE

Endotoxin
< 0.1 EU per μg of the protein as determined by the LAL method

Activity
Measured in a cell proliferation assay using BaF3 mouse pro‑B cells transfected with human FGF RIIIc. The ED50 for this effect is 0.06-0.4 µg/mL.

Storage
-80 °C, avoid repeated freeze-thaw cycles.

Storage Buffer
PBS