In the fall, we will participate in the 19th Czech Annual Cancer Research Meeting, which will take place in Olomouc from November 18 to 20, 2024, at the NH Collection Olomouc Congress Hotel. This pre...
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Read moreDescription
Insulin-like growth factor I, also known as somatomedin C, is the dominant effector of growth hormone IGF-I/IGF-1 induces the proliferation, migration, and differentiation of a wide variety of cell types during development and postnatally. IGF-I/IGF-1 regulates glucose and fatty acid metabolism, steroid hormone activity, and cartilage and bone metabolism. It plays an important role in muscle regeneration and tumor progression. IGF-I/IGF-1 binds IGF-I R, IGF-II R, and the insulin receptor, although its effects are mediated primarily by IGF-I R. IGF-I/IGF-1 association with IGF binding proteins increases its plasma half‑life and modulates its interactions with receptors.
Full Name
Insulin-like Growth Factor 1
Source
E. coli
Species
Human
Accession #
P05019
Molecule Weight
The mature recombinant human IGF-1 is a 7.6 kDa protein containing 70aa (G49-A118).
Purity
> 95 % as determined by SDS-PAGE
Endotoxin
< 0.1 EU per μg of the protein as determined by the LAL method
Activity
Measured in a serum-free cell proliferation assay using MCF‑7 human breast cancer cells. The ED50 for this effect is 0.3-1.5 ng/mL.
Storage
-80 °C, avoid repeated freeze-thaw cycles.
Storage Buffer
PBS