Recombinant Human GDNF

Description
Glial Cell Line-Derived Neurotrophic Factor (GDNF) is a disulfide-linked homodimeric glycoprotein that belongs to the TGF-β superfamily. It has been shown to promote the survival of various neuronal subpopulations in both the central as well as the peripheral nervous systems at different stages of their development. Cells known to express GDNF include Sertoli cells, type 1 astrocytes, Schwann cells, neurons, pinealocytes and skeletal muscle cells. Mutations in this gene may be associated with Hirschsprung disease.

 Full Name
Human Glial Cell Line-Derived Neurotrophic Factor

Source
E. coli

Species
Human

Accession #
P39905

Molecule Weight
The mature recombinant human GDNF consists of 134 amino acids (78-211) and has a predicted molecular mass of 30 kDa as a dimer.

Purity
> 95 % as determined by SDS-PAGE

Endotoxin
< 0.1 EU per μg of the protein as determined by the LAL method

Activity
The ED50 as determined by the proliferation of rat C6 cells was found to be <0.1 ng/mL

Storage
-80 ℃, avoid repeated freeze-thaw cycles.

Storage Buffer
PBS