Recombinant Human Wnt-2 Protein

Description
The Wnts is a large family of secreted proteins with roles in pattern formation, cell fate decision, axon guidance, and tumor formation. Wnt signaling induces and maintains the transformed phenotype and, in certain embryonic cell lines, supports self-renewal in the absence of significant differentiation. Elevated levels of Wnt proteins are associated with tumorigenesis and are present in numerous human breast cancers. Wnt family members are highly hydrophobic, and possess 22 to 24 conserved cysteines.
Wnt-2 has a role in activating β-catenin. It has been shown to have a role in cardiogenesis.  The protein is overexpressed in tumors and cancers. The mature region contains 24 cysteines and two potential N-linked glycosylation sites.

 Full Name
Wingless-type MMTV Integration Site Family Member 2

 Source
E. coli

Species
Human

Accession #
P09544

 Molecule Weight
The mature recombinant human Wnt-2 is a 35 kDa protein containing 335aa.

Purity
> 95 % as determined by SDS-PAGE

Endotoxin
< 0.1 EU per μg of the protein as determined by the LAL method

Storage
-80 °C, avoid repeated freeze-thaw cycles.

Storage Buffer
PBS