Recombinant Human Wnt-7b Protein

Description
The Wnts is a large family of secreted proteins with roles in pattern formation, cell fate decision, axon guidance, and tumor formation. Wnt signaling induces and maintains the transformed phenotype and, in certain embryonic cell lines, supports self-renewal in the absence of significant differentiation. Elevated levels of Wnt proteins are associated with tumorigenesis and are present in numerous human breast cancers. Wnt family members are highly hydrophobic, and possess 22 to 24 conserved cysteines.
Human Wnt‑7b is most similar to Wnt7a. It shares 80% aa sequence identity with Wnt-7a. Wnt-7b is produced by mammary duct epithelium. Wnt-7b may have a role in cartilage destruction during osteoarthritis. Wnt-7b signaling may also impact the development of the central nervous system (CNS). 

Full Name
Wingless-type MMTV Integration Site Family Member 7b

 Source
E. coli

Species
Human

Accession #
P56706

Molecule Weight
The mature recombinant human Wnt-7b is a 35.7 kDa protein containing 318aa (L32-K349).

Purity
> 95 % as determined by SDS-PAGE

Endotoxin
< 0.1 EU per μg of the protein as determined by the LAL method

Storage
-80 °C, avoid repeated freeze-thaw cycles.

Storage Buffer
PBS