RET Gene Fusions Detection Kit

The RET proto-oncogene encodes a receptor tyrosine kinase for members of theglial cell line-derived neurotrophic factor family of extracellular signaling molecules.Seok et al.[1] reported a novel fusion gene between KIF5B and RET proto-oncogenecaused by a pericentric inversion of 10p11.22-q11.21. This fusion geneoverexpresses chimeric RET receptor tyrosine kinase, which could spontaneouslyinduce cellular transformation.Kohno et al. [2] identified in-frame fusion transcripts ofKIF5B and the RET oncogene, which are present in 1–2% of lung adenocarcinomasfrom people from Japan and the United States, using whole-transcriptomesequencing. The KIF5B-RET fusion leads to aberrant activation of RET kinase and isconsidered to be a new lung cancer driver mutation. The tyrosine kinase inhibitorvandetanib inhibits RET kinase activity.