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Streptavidin is a non-glycosylated, 52.8 kDa, tetrameric bacterial protein isolated from Streptomyces avidinii with a very high affinity for biotin. Streptavidin-biotin bond is the strongest known non-covalent interaction with Kd ~10-15 M. Because streptavidin lacks any carbohydrate modification and has a near-neutral pI, it has the advantage of much lower nonspecific binding than avidin.

Biotin-protein ligase (EC 6.3.4.15) activates biotin to form biotinyl 5' adenylate and transfers the biotin to biotin-accepting proteins. It also functions as a biotin operon repressor.

ApoA1 (Apolipoprotein  A1) is synthesized in the liver and small intestine, and is the major protein component of high density lipoprotein (HDL) in the plasma. ApoA1 has a unique ability to capture and solubilize free cholesterol, and promotes cholesterol efflux from tissues to the liver for excretion. The process, called reverse cholesterol transport, is thought to inhibit atherogenesis.

CRISPR-Cas systems are powerful tools for mediating nucleic acids. Cas12a (also referred as Cpf1) nuclease belonging to the Class 2, Type V CRISPR system.

Human Nicotinamide Phosphoribosyltransferase (NAMPT) catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide.

Enterokinase (EK) is an enzyme produced by cells of the duodenum and involved in human digestion.

Human Trypsin 1, encoded by the PRSS1 gene, is also known as cationic trypsinogen. It contains a signal peptide (residues 1‑15), a pro region (residues 16‑23), and a mature chain (residues 24‑247).

The MutS DNA mismatch protein recognizes heteroduplex DNAs containing mispaired or unpaired bases.

Human Recombinant Alkyl Adenine DNA Glycosylase produced in E.Coli is a single, non-glycosylated polypeptide chain containing 306 amino acids (1-298 a.a.) and having a molecular mass of 33.9kDa (Molecular weight on SDS-PAGE will appear higher).

Endonuclease VIII from E. coli acts as both an N-glycosylase and an AP-lyase. The N-glycosylase activity releases damaged pyrimidines from double-stranded DNA, generating an apurinic (AP site).

Endonuclease V, (Endo V) is a 3'-endonuclease involved in DNA repair, which initiates removal of deaminated bases from damaged DNA, including uracil, hypoxanthine, and xanthine.

Endonuclease III (Nth) protein from E. coli acts as both N-glycosylase and a AP-lyase. The N-glycosylase activity releases damaged pyrimidines from double-stranded DNA, generating a basic (AP site).

RNase H is an endoribonuclease which degrades the RNA strand of RNA/DNA hybrid molecules.

RNase H is an endoribonuclease which degrades the RNA strand of RNA/DNA hybrid molecules.

RNase R is an E. coli exoribonuclease which exhibits 3' to 5' exonuclease activity, efficiently digesting nearly all linear RNA species. This enzyme does not digest circular, lariat, or double stranded RNA with short 3 overhangs (less than seven nucleotides).

Benzonase endonuclease from Serratia marcescens, can be used to degrade all forms of DNA and RNA while having no proteolytic activity.

Terminal deoxynucleotidyl transferase (TdT) is a template-independent DNA polymerase that catalyzes the addition of deoxynucleotides to the 3’ hydroxyl terminus of single or double stranded DNA molecules.

MCMax Cell-Free DNA Extraction Kit is designed to purify cell-free DNA (cfDNA) from 0.2–10 ml plasma samples. The kit contains everything necessary for purification, with no preprocessing required. The purified cell-free DNA is of high quality with little genomic DNA contamination and is ready for use in downstream applications such as qPCR, next-generation sequencing and digital PCR.

The 2X MCAmp library amplification master mix has been specially formulated to provide accurate and robust amplification of NGS (next-generation sequencing) library fragments.

The Blunting Express Kit can be used to generate blunt-ended DNA fragments for subsequent use in ligation, cloning, cDNA construction, and MCLAB’s Topomize Amplicon Library Prep Kit (Cat# TopoA-50A or TopoA-50B).  Our proprietary enzyme mix effectively fills in 5’ overhangs and eliminates A-tailed 3’ overhangs on the template.

5´ DNA Adenylation Kit is for the enzymatic synthesis of 5’ adenylated ssDNA linkers.

MCMag™ Library Purification kit is a highly efficient purification system with size selection for NGS library after PCR enrichment.

MCLab’s NGS Library Distribution Kit offers fast and reliable separation, sizing and quantification of DNA or RNA libraries utilizing Capillary Electrophoresis technology, which can separate molecules with a single base difference.

MCLab’s DNA Fragment Size Analysis Kit offers fast and reliable separation, sizing and quantification of DNA or RNA libraries utilizing Capillary Electrophoresis technology, which can separate molecules with a single base difference.